Article
Roles for an Epo receptor Tyr-343 Stat5 pathway in proliferative co-signaling with kit.
The Journal of biological chemistry - 17 Oct 2003
Li Ke, Miller Chris, Hegde Shailajia, Wojchowski Don
Abstract excerpt
Erythroid progenitor cell expansion depends upon co-signaling by Epo receptor (EpoR) and Kit, but underlying mechanisms are incompletely understood. To quantitatively analyze EpoR contributions to co-signaling, phosphotyrosine (Tyr(P)) mutants were expressed as human epidermal growth factor (hEGF) receptor-mEpoR EE chimeras at matched and physiological levels in FDCW2 hematopoietic progenitor cells and were...
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