The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains.

doi:10.1128/mcb.11.4.1980-1987.1991

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Article

The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains.

Molecular and cellular biology - 1 Apr 1991

D'Andrea A D, Yoshimura A, Youssoufian H, Zon L I, Koo J W, Lodish H F

Abstract excerpt

The erythropoietin (EPO) receptor (EPO-R), a member of a large cytokine receptor superfamily, has a 236-amino-acid cytoplasmic region which contains no obvious tyrosine kinase or other catalytic domain. In order to delineate the linear functional domains of the cytoplasmic tail, we generated truncated mutant cDNAs which were transfected into a murine interleukin-3-dependent cell line, Ba/F3, and the EPO-dependent...

Topics

Animals
Cell Division
Cells, Cultured
Cloning, Molecular
Cytoplasm
Endocytosis
Erythropoietin
Gene Expression
Interleukin-3
Kinetics
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Precipitin Tests

Receptors, Cell Surface

Receptors, Erythropoietin

Receptors, Interleukin-2

Regulatory Sequences, Nucleic Acid

Signal Transduction

Source

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Identifiers

PMID: 1848667
DOI: 10.1128/mcb.11.4.1980-1987.1991
PMCID: PMC359883

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1848667-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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