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Article

The SH2 inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin receptor.

The Journal of biological chemistry - 11 Feb 2000

Mason J M, Beattie B K, Liu Q, Dumont D J, Barber D L

Abstract excerpt

Ship1 (SH2 inositol 5-phosphatase 1) has been shown to be a target of tyrosine phosphorylation downstream of cytokine and immunoregulatory receptors. In addition to its catalytic activity on phosphatidylinositol substrates, it can serve as an adaptor protein in binding Shc and Grb2. Erythropoietin (EPO), the primary regulator of erythropoiesis, has been shown to activate the tyrosine phosphorylation of Shc,...

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Share to Adaptor Proteins, Vesicular Transport
Share to Erythropoietin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to GRB2 Adaptor Protein

Share to Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases

Share to Phosphotyrosine

Share to Receptors, Erythropoietin

Share to Shc Signaling Adaptor Proteins

Share to Src Homology 2 Domain-Containing, Transforming Protein 1

Source

Identifiers

PMID: 10660611
DOI: 10.1074/jbc.275.6.4398

Genes

EPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The SH2 inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin receptor.PMID 10660611Read ↗

The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells.Semantic proximity Read ↗

BCR/ABL Directly Inhibits Expression of SHIP, an SH2-Containing Polyinositol-5-Phosphatase Involved in the Regulation of HematopoiesisSemantic proximity Read ↗

Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-gamma 1 in a human erythropoietin-dependent cell line.Semantic proximity Read ↗

Regulation of erythropoietin-induced STAT serine phosphorylation by distinct mitogen-activated protein kinases.Semantic proximity Read ↗

The role of SHIP in cytokine-induced signaling.Semantic proximity Read ↗

The erythropoietin receptor: biogenesis, dimerization, and intracellular signal transduction.Semantic proximity Read ↗

Erythropoietin regulation of red blood cell production: from bench to bedside and backSemantic proximity Read ↗

Effects of overexpression of the SH2-containing inositol phosphatase SHIP on proliferation and apoptosis of erythroid AS-E2 cells.Semantic proximity Read ↗

Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response.Semantic proximity Read ↗

Survival and proliferative roles of erythropoietin beyond the erythroid lineageSemantic proximity Read ↗

P38α/JNK signaling restrains erythropoiesis by suppressing Ezh2-mediated epigenetic silencing of BimSemantic proximity Read ↗

Induction of tyrosine phosphorylation by the erythropoietin receptor correlates with mitogenesis.Semantic proximity Read ↗

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