Article
Altered pathogenicity in the liver induced by a mouse hepatitis virus type 3 thermosensitive mutant.
Journal of hepatology - 1 Jul 1991
Martin J P, Bingen A, Koehren F, Gut J P, Kirn A
Abstract excerpt
Intraperitoneal inoculation into sensitive BALB/c mice of D85, a thermosensitive (ts) mutant, provokes acute hepatitis followed by recovery of the mice. The ts mutant was able to replicate in the liver. However, the maximal viral titre was obtained 2 days later than was the case with the wild-type (wt) MHV 3 infection; the viral antigens remained localized within small foci and no invasion of the entire liver was...
Topics
- Animals
- Antigens, Viral
- Fluorescent Antibody Technique
- Freeze Fracturing
- Liver
- Mice
- Mice, Inbred BALB C
- Microscopy, Electron
- Murine hepatitis virus
- Mutation
- RNA, Viral