Article
Microheterogeneity of S-glycoprotein of mouse hepatitis virus temperature-sensitive mutants.
Journal of virological methods - 1 Jul 1992
Oleszak E L, Knisley K, Rodkey L S, Leibowitz J L
Abstract excerpt
Mouse hepatitis virus (MHV) strain JHM (MHV-JHM) is a neurotropic coronavirus that causes acute fatal encephalomyelitis in 75-99% of infected mice. The surviving animals may subsequently develop demyelinating disease. We compared the S peplomer protein of the wild type (wt) and five temperature-sensitive (ts) mutants of MHV-JHM. In contrast with the wt, none of these five cause fatal disease (mortality less than...
Topics
- Animals
- Glycoproteins
- Hot Temperature
- Isoelectric Focusing
- L Cells
- Mice
- Murine hepatitis virus
- Mutation
- Sensitivity and Specificity
- Viral Structural Proteins