Defect in the development of thermotolerance and enhanced heat shock protein synthesis in the mouse temperature-sensitive mutant ts85 cells upon moderate hyperthermia.

Abstract excerpt

The effect of exposure to moderate hyperthermia on the induction of thermotolerance and heat shock protein (HSP) synthesis was investigated using mouse FM3A cells and the temperature-sensitive mutant ts85 cells. The thermal sensitivity of the two cell lines was markedly different; the mutant ts85 cells were more sensitive than the parental wild-type FM3A cells to heating at 41 and 44 degrees C. The shift-up...

Topics

• Animals
• Cell Line
• Heat-Shock Proteins
• Hot Temperature
• Mice
• Mutation
• Temperature
• Ubiquitins