Studies of the pathogenesis of wild-type virus and six temperature-sensitive mutants of mouse cytomegalovirus.

Abstract excerpt

A comparison of six temperature-sensitive (ts) mutants with the parental wild-type (wt) virus showed that, when 1-week-old BALB/c mice were inoculated intraperitoneally with 300 pfu of mouse passaged virus, the viruses could be broadly categorized into two groups. Two viruses (wt and tsm6) were lethal at this dose (10 and 2 LD50 respectively); animals died within 4-6 days of inoculation and the virus became...

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