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Article

Hyaluronan-CD44 interaction stimulates keratinocyte differentiation, lamellar body formation/secretion, and permeability barrier homeostasis.

The Journal of investigative dermatology - 1 Jun 2006

Bourguignon Lilly Y W, Ramez Mohamed, Gilad Eli, Singleton Patrick A, Man Mao-Qiang, Crumrine Debra A, Elias Peter M, Feingold Kenneth R

Abstract excerpt

In this study we investigated whether hyaluronan (HA)-CD44 interaction influences epidermal structure and function. Our data show that CD44 deficiency is accompanied by reduction in HA staining in CD44 knockout (k/o) mouse skin leading to a marked thinning of epidermis versus wild-type mouse skin. A significant delay in the early barrier recovery (following acute barrier disruption) occurs in CD44 k/o versus...

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Source

Identifiers

PMID: 16557236
DOI: 10.1038/sj.jid.5700260

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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