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Article

Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway.

The American journal of pathology - 1 Oct 2009

List Karin, Kosa Peter, Szabo Roman, Bey Alexandra L, Wang Chao Becky, Molinolo Alfredo, Bugge Thomas H

Abstract excerpt

A pericellular proteolytic pathway initiated by the transmembrane serine protease matriptase plays a critical role in the terminal differentiation of epidermal tissues. Matriptase is constitutively expressed in multiple other epithelia, suggesting a putative role of this membrane serine protease in general epithelial homeostasis. Here we generated mice with conditional deletion of the St14 gene, encoding...

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Identifiers

PMID: 19717635
DOI: 10.2353/ajpath.2009.090240
PMCID: PMC2751542

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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