Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival.

15 Jul 1996

Abstract excerpt

The integrin heterodimer alpha 6 beta 4 is expressed in many epithelia and in Schwann cells. In stratified epithelia, alpha 6 beta 4 couple with BPAG1-e and BPAG2 to form hemidesmosomes, attaching externally to laminin and internally to the keratin cytoskeleton. To explore the function of this atypical integrin, and its relation to conventional actin-associated integrins, we targeted the removal of the beta 4...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Connective tissue disorders research
Share to Skin and Cellular Biology Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8707838
DOI: 10.1083/jcb.134.2.559

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival.PMID 8707838Read ↗

Keratinocytes display normal proliferation, survival and differentiation in conditional beta4-integrin knockout mice.Semantic proximity Read ↗

Deficiency of the integrin β4 subunit in junctional epidermolysis bullosa with pyloric atresia: consequences for hemidesmosome formation and adhesion propertiesSemantic proximity Read ↗

Hemidesmosomes regulate epidermal differentiation during embryogenesisSemantic proximity Read ↗

A Skin-depth Analysis of Integrins: Role of the Integrin Network in Health and DiseaseSemantic proximity Read ↗

Integrin mutations in blistering skin diseases and related genetically engineered mouse models.Semantic proximity Read ↗

Integrins in regulation of tissue development and functionSemantic proximity Read ↗

Partial rescue of epithelial phenotype in integrin beta4 null mice by a keratin-5 promoter driven human integrin beta4 transgene.Semantic proximity Read ↗

The Role of Integrins in the Development and Homeostasis of the Epidermis and Skin AppendagesSemantic proximity Read ↗

Dual Role of alpha6beta4 integrin in epidermal tumor growth: tumor-suppressive versus tumor-promoting function.Semantic proximity Read ↗

Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse.Semantic proximity Read ↗

Expression of the integrin alpha 6 beta 4 in peripheral nerves: localization in Schwann and perineural cells and different variants of the beta 4 subunit.Semantic proximity Read ↗

Integrins and morphogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.