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Article

Keratinocytes display normal proliferation, survival and differentiation in conditional beta4-integrin knockout mice.

Journal of cell science - 1 Mar 2005

Raymond Karine, Kreft Maaike, Janssen Hans, Calafat Jero, Sonnenberg Arnoud

Abstract excerpt

The alpha6beta4 integrin is located at the basal surface of keratinocytes, in hemidesmosomal structures that mediate stable adhesion of epidermal cells to the underlying basement membrane component laminin-5. The absence of alpha6beta4 integrin causes junctional epidermolysis bullosa, a severe blistering disease of the skin leading to perinatal death, confirming its essential role in mediating strong keratinocyte...

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Basement Membrane
Bromodeoxyuridine
Immunoprecipitation
In Situ Nick-End Labeling
Keratinocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microscopy, Confocal

Microscopy, Phase-Contrast

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PMID: 15731010
DOI: 10.1242/jcs.01689

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Keratinocytes display normal proliferation, survival and differentiation in conditional beta4-integrin knockout mice.PMID 15731010Read ↗

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