Article
Single nucleotide polymorphisms (SNPs) at CDH1 promoter region in familial gastric cancer.
Revista espanola de enfermedades digestivas - 1 Jan 2006
Ramos-de la Medina A, More H, Medina-Franco H, Humar B, Gamboa A, Ortiz L J, Donohue J H, Guilford P
Abstract excerpt
INTRODUCTION: Gastric cancer is the most frequent gastrointestinal malignancy in Mexico and the proportion of patients younger than 40 years is one of the highest reported in the world literature. Recently several families with familial diffuse gastric cancer have been identified at the National Institute of Medical Sciences and Nutrition. Germline mutations in the E-cadherin gene (CHD1) have been described that...
Topics
- Adult
- Cadherins
- Female
- Humans
- Male
- Pedigree
- Polymorphism, Single Nucleotide
- Promoter Regions, Genetic
- Stomach Neoplasms