Article
Single nucleotide polymorphisms in the promoter region of the E-cadherin gene in gastric cancer: case-control study in a young Mexican population.
Annals of surgical oncology - 1 Aug 2007
Medina-Franco Heriberto, Ramos-De la Medina Antonio, Vizcaino Gloria, Medina-Franco Jose Luis
Abstract excerpt
BACKGROUND: Gastric cancer has a tendency to present at early age in the Mexican population, and it is frequently associated with a family history. A polymorphism at position -160 at the CDH1 promoter region has been reported to lead to transcriptional downregulation of the gene in vitro, with possible increase in the risk of gastric cancer. We evaluated the role of the -160A allele in the risk of gastric cancer...
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