Article
Association of genetic variants in and promoter hypermethylation of CDH1 with gastric cancer: a meta-analysis.
Medicine - 1 Oct 2014
Jing Huiquan, Dai Fei, Zhao Chuntao, Yang Juan, Li Lizhuo, Kota Pravina, Mao Lijuan, Xiang Kaimin, Zheng Changqing, Yang Jingyun
Abstract excerpt
Gastric cancer (GC) is a common cause of cancer-related death. The etiology and pathogenesis of GC remain unclear, with genetic and epigenetic factors playing an important role. Previous studies investigated the association of GC with many genetic variants in and promoter hypermethylation of E-cadherin gene (CDH1), with conflicting results reported.To clarify this inconsistency, we conducted updated meta-analyses...
Topics
- Antigens, CD
- Biomarkers, Tumor
- Cadherins
- DNA Methylation
- Epigenesis, Genetic
- Ethnicity
- Genetic Predisposition to Disease
- Genetic Variation
- Humans
- Models, Genetic
- Stomach Neoplasms