Mutations affecting beta-tubulin folding and degradation.

doi:10.1074/jbc.M513730200

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Article

Mutations affecting beta-tubulin folding and degradation.

The Journal of biological chemistry - 12 May 2006

Wang Yaqing, Tian Guoling, Cowan Nicholas J, Cabral Fernando

Abstract excerpt

Revertants of a colcemid-resistant Chinese hamster ovary cell line with an altered (D45Y) beta-tubulin have allowed the identification of four cis-acting mutations (L187R, Y398C, a 12-amino acid in-frame deletion, and a C-terminal truncation) that act by destabilizing the mutant tubulin and preventing it from incorporating into microtubules. These unstable beta-tubulins fail to form heterodimers and are...

Topics

Animals
CHO Cells
Cricetinae
Leupeptins
Microtubules
Mutation
Proteasome Endopeptidase Complex
Protein Folding
Tubulin

Source

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Identifiers

PMID: 16554299
DOI: 10.1074/jbc.M513730200
PMCID: PMC2715149

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