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Article

Mutations at leucine 215 of beta-tubulin affect paclitaxel sensitivity by two distinct mechanisms.

Biochemistry - 10 Jan 2006

Wang Yaqing, Yin Shanghua, Blade Kristie, Cooper George, Menick Donald R, Cabral Fernando

Abstract excerpt

Paclitaxel resistance mutations in Chinese hamster ovary cells frequently alter a cluster of leucine residues in the H6-H7 loop region of beta-tubulin. To gain further insight into the role of this region in microtubule assembly and drug resistance, site-directed mutagenesis was used to systematically change amino acid L215. The mutated genes were cloned into a tetracycline-regulated expression vector and...

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PMID: 16388594
DOI: 10.1021/bi051207d

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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