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Article

Paclitaxel-dependent mutants have severely reduced microtubule assembly and reduced tubulin synthesis.

Journal of cell science - 1 Sept 2002

Barlow Steven B, Gonzalez-Garay Manuel L, Cabral Fernando

Abstract excerpt

A subset of mutant cell lines selected for resistance to the antitumor drug paclitaxel are unable to progress normally through mitosis unless the drug is present in the growth medium. Without paclitaxel the cells form defective spindles, undergo aberrant mitoses, fail to complete cell division and eventually die. Analysis of these drug-dependent cells revealed a low amount of microtubule polymer and less tubulin...

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Source

Identifiers

PMID: 12154077
DOI: 10.1242/jcs.115.17.3469

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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