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Article

Intra-allelic suppression of a mutation that stabilizes microtubules and confers resistance to colcemid.

Biochemistry - 20 Jul 2004

Wang Yaqing, Veeraraghavan Sudha, Cabral Fernando

Abstract excerpt

Cmd 4 is a colcemid resistant beta-tubulin mutant of Chinese hamster ovary cells that exhibits hypersensitivity to paclitaxel and temperature sensitivity for growth. The mutant beta-tubulin allele in this cell line encodes a D45Y amino acid substitution that produces colcemid resistance by making microtubules more stable. By selecting revertants of the temperature sensitive and paclitaxel hypersensitive...

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Source

Identifiers

PMID: 15248754
DOI: 10.1021/bi049637b

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Intra-allelic suppression of a mutation that stabilizes microtubules and confers resistance to colcemid.PMID 15248754Read ↗

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