Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Improvement of neutralizing activity of human scFv antibodies against hepatitis B virus binding using CDR3 V(H) mutant library.

Viral immunology - 1 Jan 2006

Park Sae-Gwang, Jung Young-Joo, Lee Young-Yi, Yang Cheul-Min, Kim Ik-Jung, Chung Jun-Ho, Kim Ik-Sang, Lee Youn-Jae, Park Sung-Jae, Lee Jeong-Nyeo, Seo Su-Kil, Park Yong-Hong, Choi In-Hak

Abstract excerpt

CDR3 of the heavy-chain variable region of immunoglobulin is a region in which somatic mutation occurs heavily after secondary antibody response, resulting in an affinity maturation of antibodies in vivo. The aim of this study was to improve the affinity of a human single-chain variable fragment (scFv) specific for pre-S1 of hepatitis B virus (HBV) by introducing random mutagenesis in CDR3 variable region of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Hepatitis B Antibodies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis B virus

Share to Immunoglobulin G

Share to Immunoglobulin Variable Region

Share to Neutralization Tests

Share to Peptide Library

Share to Protein Binding

Source

Identifiers

PMID: 16553557
DOI: 10.1089/vim.2006.19.115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Improvement of neutralizing activity of human scFv antibodies against hepatitis B virus binding using CDR3 V(H) mutant library.PMID 16553557Read ↗

Selection of affinity-improved neutralizing human scFv against HBV PreS1 from CDR3 VH/VL mutant library.Semantic proximity Read ↗

Single Chain Fragment Variable (scFv) corresponding to a novel epitope within HCV envelope protein restricts virus entry into hepatocytesSemantic proximity Read ↗

Characterization and molecular modeling of a highly stable anti-Hepatitis B surface antigen scFv.Semantic proximity Read ↗

Optimization and modification of anti-rhTNF-α single chain variable fragment antibody: effective in vitro affinity maturation and functional expression of chimeric Fab.Semantic proximity Read ↗

Improving antibody affinity through in vitro mutagenesis in complementarity determining regionsSemantic proximity Read ↗

Affinity improvement by fine tuning of single-chain variable fragment against aflatoxin B1.Semantic proximity Read ↗

Construction and Characterization of an Anti-Hepatitis B Virus preS1 Humanized Antibody that Binds to the Essential Receptor Binding Site.Semantic proximity Read ↗

Affinity maturation to improve human monoclonal antibody neutralization potency and breadth against hepatitis C virus.Semantic proximity Read ↗

Improved antigen binding by a CD20-specific single-chain antibody fragment with a mutation in CDRH1.Semantic proximity Read ↗

Isolation and characterization of a novel human scFv inhibiting EGFR vIII expressing cancers.Semantic proximity Read ↗

Affinity improvement of the fully human anti‑TSLP recombinant antibody.Semantic proximity Read ↗

Mammalian cell display for rapid screening scFv antibody therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.