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Article

Rapid selection of specific MAP kinase-binders from designed ankyrin repeat protein libraries

21 Mar 2006

Abstract excerpt

We describe here the rapid selection of specific MAP-kinase binders from a combinatorial library of designed ankyrin repeat proteins (DARPins). A combined in vitro/in vivo selection approach, based on ribosome display and the protein fragment complementation assay (PCA), yielded a large number of different binders that are fully functional in the cellular cytoplasm. Ribosome-display selection pools of four...

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PMID: 16551653
DOI: 10.1093/protein/gzl004

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Source receipt: pubmed, retrieved 7 Sept 2026.

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