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Article

ANKRD54 preferentially selects Bruton's Tyrosine Kinase (BTK) from a Human Src-Homology 3 (SH3) domain library.

PloS one - 1 Jan 2017

Gustafsson Manuela O, Mohammad Dara K, Ylösmäki Erkko, Choi Hyunseok, Shrestha Subhash, Wang Qing, Nore Beston F, Saksela Kalle, Smith C I Edvard

Abstract excerpt

Bruton's Tyrosine Kinase (BTK) is a cytoplasmic protein tyrosine kinase with a fundamental role in B-lymphocyte development and activation. The nucleocytoplasmic shuttling of BTK is specifically modulated by the Ankyrin Repeat Domain 54 (ANKRD54) protein and the interaction is known to be exclusively SH3-dependent. To identify the spectrum of the ANKRD54 SH3-interactome, we applied phage-display screening of a...

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Identifiers

PMID: 28369144
DOI: 10.1371/journal.pone.0174909
PMCID: PMC5378395

Genes

BTK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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