Article
Intracellular kinase inhibitors selected from combinatorial libraries of designed ankyrin repeat proteins.
The Journal of biological chemistry - 1 Jul 2005
Amstutz Patrick, Binz H Kaspar, Parizek Petra, Stumpp Michael T, Kohl Andreas, Grütter Markus G, Forrer Patrik, Plückthun Andreas
Abstract excerpt
The specific intracellular inhibition of protein activity at the protein level allows the determination of protein function in the cellular context. We demonstrate here the use of designed ankyrin repeat proteins as tailor-made intracellular kinase inhibitors. The target was aminoglycoside phosphotransferase (3')-IIIa (APH), which mediates resistance to aminoglycoside antibiotics in pathogenic bacteria and shares...
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