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Article

Origin and Molecular Evolution of Receptor Tyrosine Kinases with Immunoglobulin-Like Domains

21 Mar 2006

Abstract excerpt

Receptor tyrosine kinases (RTKs) are involved in the control of fundamental cellular processes in metazoans. In vertebrates, RTK could be grouped in distinct classes based on the nature of their cognate ligand and modular composition of their extracellular domain. RTK with immunoglobulin-like domains (IG-like RTK) encompass several RTK classes and have been found in early metazoans, including sponges. Evolution...

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PMID: 16551648
DOI: 10.1093/molbev/msk007

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