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Article

Natural history and functional divergence of protein tyrosine kinases.

Gene - 23 Oct 2003

Gu Jianying, Gu Xun

Abstract excerpt

Cellular signaling is important for many biological processes including growth, differentiation, adhesion, motility and apoptosis. The protein tyrosine kinase (PTK) supergene family is the key mediator in cellular signaling in metazoans, directly associated with a variety of human diseases. All PTKs contain a highly conserved catalytic kinase domain, in spite of variable multi-domain structures. Within each PTK...

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PMID: 14604791
DOI: 10.1016/s0378-1119(03)00696-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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