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Article

Ancient divergence of a complex family of immune-type receptor genes.

Immunogenetics - 1 Jun 2006

Cannon John P, Haire Robert N, Mueller M Gail, Litman Ronda T, Eason Donna D, Tinnemore Deborah, Amemiya Chris T, Ota Tatsuya, Litman Gary W

Abstract excerpt

Multigene families of activating/inhibitory receptors belonging to the immunoglobulin superfamily (IgSF) regulate immunological and other cell-cell interactions. A new family of such genes, termed modular domain immune-type receptors (MDIRs), has been identified in the clearnose skate (Raja eglanteria), a phylogenetically ancient vertebrate. At least five different major forms of predicted MDIR proteins are...

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Identifiers

PMID: 16738934
DOI: 10.1007/s00251-006-0112-7
PMCID: PMC3701310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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