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Article

The phylogenetic origins of the antigen-binding receptors and somatic diversification mechanisms.

Immunological reviews - 1 Aug 2004

Cannon John P, Haire Robert N, Rast Jonathan P, Litman Gary W

Abstract excerpt

The adaptive immune system arose in ancestors of the jawed vertebrates approximately 500 million years ago. Homologs of immunoglobulins (Igs), T-cell antigen receptors (TCRs), major histocompatibility complex I (MHC I) and MHC II, and the recombination-activating genes (RAGs) have been identified in all extant classes of jawed vertebrates; however, no definitive homolog of any of these genes has been identified...

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Source

Identifiers

PMID: 15242392
DOI: 10.1111/j.0105-2896.2004.00166.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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