Article
C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein.
Current biology : CB - 11 Dec 2001
Ahmed S, Alpi A, Hengartner M O, Gartner A
Abstract excerpt
BACKGROUND: In response to genotoxic stress, cells activate checkpoint pathways that lead to a transient cell cycle arrest that allows for DNA repair or to apoptosis, which triggers the demise of genetically damaged cells. RESULTS: During positional cloning of the C. elegans rad-5 DNA damage checkpoint gene, we found, surprisingly, that rad-5(mn159) is allelic with clk-2(qm37), a mutant previously implicated in...
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