Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Zygotic Genome Activation Triggers Chromosome Damage and Checkpoint Signaling in C. elegans Primordial Germ Cells.

Developmental cell - 6 Jul 2015

Butuči Melina, Williams Ashley B, Wong Matthew M, Kramer Brendan, Michael W Matthew

Abstract excerpt

Recent findings have identified highly transcribed genes as a source of genome instability; however, the degree to which large-scale shifts in transcriptional activity cause DNA damage was not known. One example of a large-scale shift in transcriptional activity occurs during development, when ma...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins
Share to Cell Cycle Checkpoints

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Damage

Share to Genomic Instability

Share to Germ Cells

Share to Mutation

Share to Zygote

Source

Identifiers

PMID: 26073019
DOI: 10.1016/j.devcel.2015.04.019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26073019-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Zygotic Genome Activation Triggers Chromosome Damage and Checkpoint Signaling in C. elegans Primordial Germ Cells.PMID 26073019Read ↗

Programmed DNA Breaks Activate the Germline Genome in Caenorhabditis elegans.Semantic proximity Read ↗

The zinc-finger transcription factor LSL-1 is a major regulator of the germline transcriptional program in <i>C. elegans</i>Semantic proximity Read ↗

The <i>C. elegans</i> SET-2 histone methyltransferase maintains germline fate by preventing progressive transcriptomic deregulation across generationsSemantic proximity Read ↗

Germline chromatinSemantic proximity Read ↗

NuRD chromatin remodeling is required to repair exogenous DSBs in the <i>Caenorhabditis elegans</i> germlineSemantic proximity Read ↗

The condensin II/TOP-2 axis silences transcription during germline specification in <i>C. elegans</i>Semantic proximity Read ↗

Spatiotemporal Gene Expression Analysis of theCaenorhabditis elegansGermline Uncovers a Syncytial Expression SwitchSemantic proximity Read ↗

Global Transcriptional Repression in C. elegans Germline Precursors by Regulated Sequestration of TAF-4Semantic proximity Read ↗

Tolerance thresholds underlie responses to DNA damage during germline developmentSemantic proximity Read ↗

Trajectory Mapping of the Early <i>Drosophila</i> Germline Reveals Controls of Zygotic Activation and Sex DifferentiationSemantic proximity Read ↗

Developmentally programmed epigenome regulates cellular plasticity at the parental-to-zygote transitionSemantic proximity Read ↗

Checkpoint silencing during the DNA damage response in Caenorhabditis elegans embryos.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.