Direct evidence that naturally occurring mutations within hepatitis B core epitope alter CD4+ T-cell reactivity.

doi:10.1002/jmv.20016

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Article

Direct evidence that naturally occurring mutations within hepatitis B core epitope alter CD4+ T-cell reactivity.

Journal of medical virology - 1 Mar 2004

Torre Francesco, Cramp Matthew, Owsianka Ania, Dornan Ed, Marsden Howard, Carman William, Williams Roger, Naoumov Nikolai V

Abstract excerpt

Exacerbations of chronic hepatitis B have been associated with accumulation of mutations in the HBV core gene, with amino acid (aa) substitutions clustering between aa 50 and 69. This region of the nucleocapsid protein is known as an immunodominant epitope for CD4+ T-lymphocytes, however the impact of these mutations on T-cell reactivity has not been investigated. For this purpose, we undertook fine mapping of...

Topics

Adolescent
Adult
Aged
Amino Acid Sequence
CD4-Positive T-Lymphocytes
Female
Hepatitis B
Hepatitis B Core Antigens
Hepatitis B virus
Hepatitis B, Chronic
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunodominant Epitopes

Lymphocyte Activation

Male

Middle Aged

Molecular Sequence Data

Mutation

Peptides

Source

Open in PubMed

Identifiers

PMID: 14748060
DOI: 10.1002/jmv.20016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Direct evidence that naturally occurring mutations within hepatitis B core epitope alter CD4+ T-cell reactivity.PMID 14748060Read ↗

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