Article
Recognition of core-derived epitopes from a novel HBV-targeted immunotherapeutic by T-cells from patients infected by different viral genotypes.
Vaccine - 26 Aug 2015
Godon Ophelie, Evlachev Alexei, Bourgine Maryline, Meritet Jean-François, Martin Perrine, Inchauspe Genevieve, Michel Marie-Louise
Abstract excerpt
Hepatitis B virus (HBV) infects millions of people worldwide and is a leading cause of liver cirrhosis and hepatocellular carcinoma. Current therapies based on nucleos(t)ide analogs or pegylated-interferon-α lead to control of viral replication in most patients but rarely achieve cure. A potential strategy to control chronic hepatitis B is to restore or induce functional anti-HBV T-cell immune responses using...
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