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Article

Optimized vaccination regimen linked to exhaustive screening approaches identifies 2 novel HLA-B7 restricted epitopes within hepatitis C virus NS3 protein.

Microbes and infection - 1 Aug 2006

Martin Perrine, Parroche Peggy, Pajot Anthony, Chatel Laurence, Barreto Caroline, Touat Leila, Dubois Valérie, Rohrlich Pierre-Simon, Bain Christine, Trépo Christian, Negro Francesco, Inchauspé Geneviève, Fournillier Anne

Abstract excerpt

Broad immune responses, in particular specific for the NS3 protein and mediated by both CD8+ and CD4+T lymphocytes, are thought to play a critical role in the control of hepatitis C virus (HCV) infection. In this study, we searched for novel HLA-B*0702 NS3 restricted epitopes following an optimized NS3NS4 immunization protocol in transgenic mice expressing HLA-B*0702 molecule. Combining predicted and overlapping...

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Source

Identifiers

PMID: 16859951
DOI: 10.1016/j.micinf.2006.05.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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