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Article

The adaptor protein soc-1/Gab1 modifies growth factor receptor output in Caenorhabditis elegans.

Genetics - 1 May 2006

Hopper Neil A

Abstract excerpt

Previous genetic analysis has shown that dos/soc-1/Gab1 functions positively in receptor tyrosine kinase (RTK)-stimulated Ras/Map kinase signaling through the recruitment of csw/ptp-2/Shp2. Using sensitized assays in Caenorhabditis elegans for let-23/Egfr and daf-2/InsR (insulin receptor-like) signaling, it is shown that soc-1/Gab1 inhibits phospholipase C-gamma (PLCgamma) and phosphatidylinositol 3'-kinase...

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Identifiers

PMID: 16547100
DOI: 10.1534/genetics.106.055822
PMCID: PMC1461424

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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