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Article

The Caenorhabditis elegans protein SOC-3 permits an alternative mode of signal transduction by the EGL-15 FGF receptor.

Developmental biology - 1 Dec 2024

Rodriguez Torres Claudia S, Wicker Nicole B, Puccini de Castro Victória, Stefinko Mariya, Bennett Daniel C, Bernhardt Brooke, Garcia Montes de Oca Melissa, Jallow Sainabou, Flitcroft Katelyn, Palalay Jessica-Jae S, Payán Parra Omar A, Stern Yaakov E, Koelle Michael R, Voisine Cindy, Woods Ian G, Lo Te-Wen, Stern Michael J, de la Cova Claire C

Abstract excerpt

Fibroblast Growth Factors and their receptors (FGFRs) comprise a cell signaling module that can stimulate signaling by Ras and the kinases Raf, MEK, and ERK to regulate animal development and homeostatic functions. In Caenorhabditis elegans, the sole FGFR ortholog EGL-15 acts with the GRB2 ortholog SEM-5 to promote chemoattraction and migration by the sex myoblasts (SMs) and fluid homeostasis by the hypodermis...

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Identifiers

PMID: 39173814
DOI: 10.1016/j.ydbio.2024.08.014
PMCID: PMC11488645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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