Article
Significant gene order and expression differences in Bordetella pertussis despite limited gene content variation.
Journal of bacteriology - 1 Apr 2006
Brinig Mary M, Cummings Craig A, Sanden Gary N, Stefanelli Paola, Lawrence Andrew, Relman David A
Abstract excerpt
Bordetella pertussis, an obligate human pathogen and the agent of whooping cough, is a clonal species, despite the dynamic selection pressures imposed by host immunity and vaccine usage. Because the generation of variation is critical for species evolution, we employed a variety of approaches to examine features of B. pertussis genetic variation. We found a high level of conservation of gene content among 137 B....
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