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Global Population Structure and Evolution of Bordetella pertussis and Their Relationship with Vaccination

23 Apr 2014

Abstract excerpt

Bordetella pertussis causes pertussis, a respiratory disease that is most severe for infants. Vaccination was introduced in the 1950s, and in recent years, a resurgence of disease was observed worldwide, with significant mortality in infants. Possible causes for this include the switch from whole-cell vaccines (WCVs) to less effective acellular vaccines (ACVs), waning immunity, and pathogen adaptation. Pathogen...

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PMID: 24757216
DOI: 10.1128/mbio.01074-14

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