Article
Towards comprehensive understanding of bacterial genetic diversity: large-scale amplifications in Bordetella pertussis and Mycobacterium tuberculosis.
Microbial genomics - 1 Feb 2022
Abrahams Jonathan S, Weigand Michael R, Ring Natalie, MacArthur Iain, Etty Joss, Peng Scott, Williams Margaret M, Bready Barret, Catalano Anthony P, Davis Jennifer R, Kaiser Michael D, Oliver John S, Sage Jay M, Bagby Stefan, Tondella M Lucia, Gorringe Andrew R, Preston Andrew
Abstract excerpt
Bacterial genetic diversity is often described solely using base-pair changes despite a wide variety of other mutation types likely being major contributors. Tandem duplication/amplifications are thought to be widespread among bacteria but due to their often-intractable size and instability, comprehensive studies of these mutations are rare. We define a methodology to investigate amplifications in bacterial...
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