Article
Insight into evolution of Bordetella pertussis from comparative genomic analysis: evidence of vaccine-driven selection.
Molecular biology and evolution - 1 Jan 2011
Octavia Sophie, Maharjan Ram P, Sintchenko Vitali, Stevenson Gordon, Reeves Peter R, Gilbert Gwendolyn L, Lan Ruiting
Abstract excerpt
Despite high vaccine coverage, pertussis incidence has increased substantially in recent years in many countries. A significant factor that may be contributing to this increase is adaptation to the vaccine by Bordetella pertussis, the causative agent of pertussis. In this study, we first assessed the genetic diversity of B. pertussis by microarray-based comparative genome sequencing of 10 isolates representing...
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