Article
Comparative genomics of the classical Bordetella subspecies: the evolution and exchange of virulence-associated diversity amongst closely related pathogens.
BMC genomics - 10 Oct 2012
Park Jihye, Zhang Ying, Buboltz Anne M, Zhang Xuqing, Schuster Stephan C, Ahuja Umesh, Liu Minghsun, Miller Jeff F, Sebaihia Mohammed, Bentley Stephen D, Parkhill Julian, Harvill Eric T
Abstract excerpt
BACKGROUND: The classical Bordetella subspecies are phylogenetically closely related, yet differ in some of the most interesting and important characteristics of pathogens, such as host range, virulence and persistence. The compelling picture from previous comparisons of the three sequenced genomes was of genome degradation, with substantial loss of genome content (up to 24%) associated with adaptation to humans....
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