Article
Induction of efficient apoptosis and cell-cycle arrest in tumor cells by adenovirus-mediated p53 A4 mutant.
Pathology international - 1 Mar 2006
Maeda Akihiro, Nakamura Seiichi, Isono Masato, Osaki Mitsuhiko, Ito Hisao, Sato Kenzo
Abstract excerpt
p53 is an effective tumor suppressor and is inactivated in numerous cancer cells. In the present study, p53 mutant A4, which carries mutations in C-terminus of the protein and is resistant to murine double minute 2-mediated degradation, was exploited to introduce p53 function in tumor cells. The effect of p53 A4 mutant with recombinant adenovirus vector (Ad-p53 A4) was examined. Ad-p53 A4 infection at a low...
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