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Article

Cerebrospinal fluid levels of beta-amyloid(42) in patients with Alzheimer's disease are related to the exon 2 polymorphism of the cathepsin D gene.

Neuroreport - 19 Jul 2002

Papassotiropoulos Andreas, Lewis Huw D, Bagli Metin, Jessen Frank, Ptok Ursula, Schulte Andrea, Shearman Mark S, Heun Reinhard

Abstract excerpt

The intracellular aspartyl protease cathepsin D (catD) is involved in such Alzheimer's disease (AD)-related processes as the activation of the endosomal/lysosomal system and the cleavage of the amyloid precursor protein into amyloidogenic components, which may initiate neurodegeneration. A non-synonymous polymorphism (exon 2, C to T exchange leading to ala-->val substitution) of the gene encoding catD (CTSD) was...

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Source

Identifiers

PMID: 12151789
DOI: 10.1097/00001756-200207190-00015

Genes

CTSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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