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Article

Modulation of disease risk according to a cathepsin D / apolipoprotein E genotype in Parkinson's disease.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Jul 2003

Schulte T, Böhringer S, Schöls L, Müller T, Fischer C, Riess O, Przuntek H, Berger K, Epplen J T, Krüger R

Abstract excerpt

Aspartyl protease Cathepsin D (CTSD) has been suggested to play a role in the pathogenesis of sporadic Alzheimer's disease (AD) due to interference with protein degradation mechanisms. A C224T (A38V) polymorphism in exon 2 of the CTSD gene is reported to be associated with an increased risk for AD. The partially overlapping pathology between AD and Parkinson's disease (PD) led us to investigate the role of this...

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Source

Identifiers

PMID: 12811635
DOI: 10.1007/s00702-003-0832-x

Genes

CTSD
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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