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Article

Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus.

Science (New York, N.Y.) - 21 Apr 2006

Stevens James, Blixt Ola, Tumpey Terrence M, Taubenberger Jeffery K, Paulson James C, Wilson Ian A

Abstract excerpt

The hemagglutinin (HA) structure at 2.9 angstrom resolution, from a highly pathogenic Vietnamese H5N1 influenza virus, is more related to the 1918 and other human H1 HAs than to a 1997 duck H5 HA. Glycan microarray analysis of this Viet04 HA reveals an avian alpha2-3 sialic acid receptor binding preference. Introduction of mutations that can convert H1 serotype HAs to human alpha2-6 receptor specificity only...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemagglutinin Glycoproteins, Influenza Virus

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Source

Identifiers

PMID: 16543414
DOI: 10.1126/science.1124513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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