Article
Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza H5N1 viruses.
Virology - 25 Apr 2011
Maines Taronna R, Chen Li-Mei, Van Hoeven Neal, Tumpey Terrence M, Blixt Ola, Belser Jessica A, Gustin Kortney M, Pearce Melissa B, Pappas Claudia, Stevens James, Cox Nancy J, Paulson James C, Raman Rahul, Sasisekharan Ram, Katz Jacqueline M, Donis Ruben O
Abstract excerpt
Although H5N1 influenza viruses have been responsible for hundreds of human infections, these avian influenza viruses have not fully adapted to the human host. The lack of sustained transmission in humans may be due, in part, to their avian-like receptor preference. Here, we have introduced receptor binding domain mutations within the hemagglutinin (HA) gene of two H5N1 viruses and evaluated changes in receptor...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.