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Article

Glycan topology determines human adaptation of avian H5N1 virus hemagglutinin.

Nature biotechnology - 1 Jan 2008

Chandrasekaran Aarthi, Srinivasan Aravind, Raman Rahul, Viswanathan Karthik, Raguram S, Tumpey Terrence M, Sasisekharan V, Sasisekharan Ram

Abstract excerpt

A switch in specificity of avian influenza A viruses' hemagglutinin (HA) from avian-like (alpha2-3 sialylated glycans) to human-like (alpha2-6 sialylated glycans) receptors is believed to be associated with their adaptation to infect humans. We show that a characteristic structural topology--and not the alpha2-6 linkage itself--enables specific binding of HA to alpha2-6 sialylated glycans and that recognition of...

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Identifiers

PMID: 18176555
DOI: 10.1038/nbt1375

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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