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Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin

10 Dec 2012

Abstract excerpt

The hemagglutinin (HA) of influenza A(H3N2) virus responsible for the 1968 influenza pandemic derived from an avian virus. On introduction into humans, its receptor binding properties had changed from a preference for avian receptors (α2,3-linked sialic acid) to a preference for human receptors (α2,6-linked sialic acid). By 2001, the avidity of human H3 viruses for avian receptors had declined, and since then the...

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PMID: 23236176
DOI: 10.1073/pnas.1218841110

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