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Article

Structural determinants for naturally evolving H5N1 hemagglutinin to switch its receptor specificity.

Cell - 20 Jun 2013

Tharakaraman Kannan, Raman Rahul, Viswanathan Karthik, Stebbins Nathan W, Jayaraman Akila, Krishnan Arvind, Sasisekharan V, Sasisekharan Ram

Abstract excerpt

Of the factors governing human-to-human transmission of the highly pathogenic avian-adapted H5N1 virus, the most critical is the acquisition of mutations on the viral hemagglutinin (HA) to "quantitatively switch" its binding from avian to human glycan receptors. Here, we describe a structural framework that outlines a necessary set of H5 HA receptor-binding site (RBS) features required for the H5 HA to...

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Identifiers

PMID: 23746829
DOI: 10.1016/j.cell.2013.05.035
PMCID: PMC3760228

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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