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Article

Evolution of the receptor binding phenotype of influenza A (H5) viruses.

Virology - 20 Jan 2006

Gambaryan Alexandra, Tuzikov Alexander, Pazynina Galina, Bovin Nicolai, Balish Amanda, Klimov Alexander

Abstract excerpt

Receptor specificity of influenza A/H5 viruses including human 2003-04 isolates was studied. All but two isolates preserved high affinity to Sia2-3Gal (avian-like) receptors. However, two isolates (February, 2003, Hong Kong) demonstrated decreased affinity to Sia2-3Gal and moderate affinity to a Sia2-6Gal (human-like) receptors. These two viruses had a unique Ser227-Asn change in the hemagglutinin molecule. Thus,...

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PMID: 16226289
DOI: 10.1016/j.virol.2005.08.035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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