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Article

ADAM17 activity during human neutrophil activation and apoptosis

16 Mar 2006

Abstract excerpt

Substrates of the metalloprotease ADAM17 (also known as TNF-alpha converting enzyme or TACE) undergo ectodomain shedding and include various inflammatory modulators. Though polymorphonuclear leukocytes contribute significantly to inflammation, direct analyses of ADAM17 on human neutrophils are very limited. In addition, the current understanding of the processes regulating ADAM17 activity primarily relate to its...

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PMID: 16541467
DOI: 10.1002/eji.200535257

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