Back to search

Article

Endothelial ADAM17 Promotes Neutrophil Migration and Pulmonary Microvascular Permeability in ARDS

2026-01-25

Abstract excerpt

Acute respiratory distress syndrome (ARDS) is characterized by profound endothelial barrier disruption, excessive neutrophil recruitment, and sustained pulmonary inflammation. A Disintegrin and Metalloproteinase 17 (ADAM17) regulates inflammatory signaling through ectodomain shedding of adhesion molecules and cytokine receptors, yet its endothelial-specific contribution to ARDS remains poorly defined. We identify...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4af02d91-2ee1-55b3-9781-ee849ea5a78d
DOI
10.64898/2026.01.21.700786
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Endothelial ADAM17 Promotes Neutrophil Migration and Pulmonary Microvascular Permeability in ARDSDOI 10.64898/2026.01.21.700786
ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte TransmigrationSemantic proximity
The shedding protease ADAM17: Physiology and pathophysiologySemantic proximity
ADAM15 regulates endothelial permeability and neutrophil migration via Src/ERK1/2 signalling.Semantic proximity
Molecular switch in human diseases-disintegrin and metalloproteinases, ADAM17Semantic proximity
Loss of ADAM17 is associated with severe multiorgan dysfunction.Semantic proximity
Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice.Semantic proximity
Macrophage ADAM17 deficiency augments CD36-dependent apoptotic cell uptake and the linked anti-inflammatory phenotype.Semantic proximity
ADAM10: Function insights, disease implications, and promise of therapeutic targetingSemantic proximity
An Overview of ADAM9: Structure, Activation, and Regulation in Human DiseasesSemantic proximity
The Role of ADAM17 in Inflammation-Related AtherosclerosisSemantic proximity
ADAM17 activity during human neutrophil activation and apoptosisSemantic proximity
The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: Novel drug targets with therapeutic potential?Semantic proximity
Select a neighboring publication to make it the new centre.