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Article

Cytokine secretion and NK cell activity in human ADAM17 deficiency.

Oncotarget - 29 Dec 2015

Tsukerman Pinchas, Eisenstein Eli M, Chavkin Maor, Schmiedel Dominik, Wong Eitan, Werner Marion, Yaacov Barak, Averbuch Diana, Molho-Pessach Vered, Stepensky Polina, Kaynan Noa, Bar-On Yotam, Seidel Einat, Yamin Rachel, Sagi Irit, Elpeleg Orly, Mandelboim Ofer

Abstract excerpt

Genetic deficiencies provide insights into gene function in humans. Here we describe a patient with a very rare genetic deficiency of ADAM17. We show that the patient's PBMCs had impaired cytokine secretion in response to LPS stimulation, correlating with the clinical picture of severe bacteremia from which the patient suffered. ADAM17 was shown to cleave CD16, a major NK killer receptor. Functional analysis of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antibody-Dependent Cell Cytotoxicity

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Share to Immunologic Deficiency Syndromes

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Source

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Identifiers

PMID: 26683521
DOI: 10.18632/oncotarget.6629
PMCID: PMC4792548

Genes

ADAM17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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